As with other benzodiazepines like Xanax (alprazolam), Klonopin (clonazepam), and Valium (diazepam), Librium has a relatively long half-life, and the time it takes to eliminate the drug from the system can vary from one person to the next.
Factors for Drug Elimination
Librium has a drug half-life of between 24 and 48 hours, meaning that 50% of the drug will have been eliminated from the body with this span of time. You may need to take a larger loading dose of Librium for a period of time to achieve the therapeutic effects. Once you gradually build up to peak concentrations in the blood, you can switch to a lower dose. When stopping Librium, the time it takes to eliminate all traces of the drug from the body can vary based upon a number of factors, including:
Your ageLiver functionBody massDosagePeriod of usageOther drugs in your systemGenetics
All of these factors contribute to how quickly or slowly you eliminate Librium from the system.
Physiological Factors
Librium is metabolized by the liver and excreted in urine. If your liver is in any way impaired, the clearance of the drug will also be impeded. This can lead to variations in the drug half-life. Age also plays a role because liver function tends to wane as we age. As a result, people over 65 end to eliminate Librium at nearly half the rate (40%) of someone in their 20s and 30s.
Pharmaceutical Factors
The higher the dosage and period of usage, the longer it will take to clear Librium from the body. Those who never quite reach peak concentration will invariably achieve clearance faster than those who do. Beyond the drug itself, Librium clearance may be affected by other drugs you are taking. Librium is primarily cleared from the body with an enzyme known as cytochrome P450 (CYP450) that metabolizes toxins in the liver.
Genetic Factors
Genetics also plays a role in that certain genetic anomalies can impede the synthesis of amino acids, the building blocks of enzymes. This can affect the level of CYP450 metabolism and, in turn, the elimination of Librium from the body. Some of these anomalies are not always readily detected.
Librium Detection by Test
Some tests are able to detect Librium well after drug levels have dropped to undetectable levels for others. The following is an estimated range of times (detection windows) during which Librium can still be reliably detected:
Blood tests: 6-48 hoursSaliva test: 1-10 daysUrine test: 1-6 weeksHair follicle test: up to 90 days
Withdrawal and Safe Elimination
If you decide to stop taking Librium (or have developed a dependence on the drug and need to detox), you should only do so under the direction of your prescribing doctor. If you stop cold turkey, you risk serious withdrawal symptoms, including:
AgitationInsomniaTremorsSweatingMuscle achesAbdominal crampsNausea or vomitingDepression and mood swingsTrouble feeling pleasure (dysphoria)
Some of these symptoms, like depression and insomnia, can persist for more than a month. To mitigate the risk, doctors will formulate a tapering process wherein the Librium dose is progressively reduced over the course of several weeks. To help speed the process, you can drink a lot of water to encourage the clearance of the drugs through the kidneys. Exercise can help speed your natural metabolism but should be advised under the care of a doctor. Excessive exercise, however, is not recommended, as it could exacerbate some of your withdrawal symptoms.
A Word From Verywell
Because Librium is a benzodiazepine, extra care should be taken if an opioid drug is co-prescribed for pain. The FDA has found serious risks associated with the co-administration of these drugs, including the potentially life-threatening depression of the central nervous system. Because of these risks, the FDA has issued its strongest warning on opioid and benzodiazepine labels. The combined use of these drugs may result in respiratory arrest and death. Alcohol can trigger the same effects and should be avoided if you taking Librium. If you suspect a Librium overdose, call 911 or the National Poison Control Center at 1-800-222-1222.
